After-Hours Mutant Reveals a Role for Fbxl3 in Determining Mammalian Circadian Period
After-Hours Mutant Reveals a Role for Fbxl3 in Determining Mammalian Circadian Period
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Washington, DC: American Association for the Advancement of Science
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English
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Washington, DC: American Association for the Advancement of Science
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By screening N-ethyl-N-nitrosourea-mutagenized animals for alterations in rhythms of wheel-running activity, we identified a mouse mutation, after hours (Afh). The mutation, a Cys³⁵⁸Ser substitution in Fbxl3, an F-box protein with leucine-rich repeats, results in long free-running rhythms of about 27 hours in homozygotes. Circadian transcriptional...
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After-Hours Mutant Reveals a Role for Fbxl3 in Determining Mammalian Circadian Period
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TN_cdi_proquest_miscellaneous_743504075
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_743504075
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ISSN
0036-8075
E-ISSN
1095-9203
DOI
10.1126/science.1141138
