Vascular Abnormalities and Deregulation of VEGF in Lkb1-Deficient Mice
Vascular Abnormalities and Deregulation of VEGF in Lkb1-Deficient Mice
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Washington, DC: American Society for the Advancement of Science
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Language
English
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Washington, DC: American Society for the Advancement of Science
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Contents
The LKB1 tumor suppressor gene, mutated in Peutz-Jeghers syndrome, encodes a serine/threonine kinase of unknown function. Here we show that mice with a targeted disruption of Lkb1 die at midgestation, with the embryos showing neural tube defects, mesenchymal cell death, and vascular abnormalities. Extraembryonic development was also severely affect...
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Full title
Vascular Abnormalities and Deregulation of VEGF in Lkb1-Deficient Mice
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TN_cdi_proquest_miscellaneous_743558689
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_743558689
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ISSN
0036-8075
E-ISSN
1095-9203
DOI
10.1126/science.1062074
