Integrin CD11b negatively regulates TLR-triggered inflammatory responses by activating Syk and promo...
Integrin CD11b negatively regulates TLR-triggered inflammatory responses by activating Syk and promoting degradation of MyD88 and TRIF via Cbl-b
About this item
Full title
Author / Creator
Han, Chaofeng , Jin, Jing , Xu, Sheng , Liu, Haibo , Li, Nan and Cao, Xuetao
Publisher
New York: Nature Publishing Group US
Journal title
Language
English
Formats
Publication information
Publisher
New York: Nature Publishing Group US
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Scope and Contents
Contents
Integrins regulate the migration of leukocytes in inflammation. Cao and co-workers now show that CD11b is activated by Toll-like receptor–triggered inside-out signaling and feeds back to inhibit phosphorylation of the adaptors MyD88 and TRIF.
Integrins are critical for the migration and function of leukocytes in inflammation. However, the intera...
Alternative Titles
Full title
Integrin CD11b negatively regulates TLR-triggered inflammatory responses by activating Syk and promoting degradation of MyD88 and TRIF via Cbl-b
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Record Identifier
TN_cdi_proquest_miscellaneous_754532231
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_754532231
Other Identifiers
ISSN
1529-2908
E-ISSN
1529-2916
DOI
10.1038/ni.1908
