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Endogenous antibodies promote rapid myelin clearance and effective axon regeneration after nerve inj...

Endogenous antibodies promote rapid myelin clearance and effective axon regeneration after nerve inj...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_754537072

Endogenous antibodies promote rapid myelin clearance and effective axon regeneration after nerve injury

About this item

Full title

Endogenous antibodies promote rapid myelin clearance and effective axon regeneration after nerve injury

Publisher

United States: National Academy of Sciences

Journal title

Proceedings of the National Academy of Sciences - PNAS, 2010-06, Vol.107 (26), p.11993-11998

Language

English

Formats

Publication information

Publisher

United States: National Academy of Sciences

More information

Scope and Contents

Contents

Degenerating myelin inhibits axon regeneration and is rapidly cleared after peripheral (PNS) but not central nervous system (CNS) injury. To better understand mechanisms underlying rapid PNS myelin clearance, we tested the potential role of the humoral immune system. Here, we show that endogenous antibodies are required for rapid and robust PNS mye...

Alternative Titles

Full title

Endogenous antibodies promote rapid myelin clearance and effective axon regeneration after nerve injury

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_proquest_miscellaneous_754537072

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_754537072

Other Identifiers

ISSN

0027-8424

E-ISSN

1091-6490

DOI

10.1073/pnas.1001948107

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