Insulin regulates the activity of forkhead transcription factor Hnf-3beta/Foxa-2 by Akt-mediated pho...
Insulin regulates the activity of forkhead transcription factor Hnf-3beta/Foxa-2 by Akt-mediated phosphorylation and nuclear/cytosolic localization
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United States: National Academy of Sciences
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English
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United States: National Academy of Sciences
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Hepatocyte nuclear factors 3 alpha, beta, and gamma (Foxa-1, -2, and -3) are transcriptional activators of important metabolic genes in the liver that are suppressed by the actions of insulin. Here, we show that the activation of phosphatidylinositol 3-kinase-Akt by insulin induces Foxa-2 phosphorylation, nuclear exclusion, and inhibition of Foxa-2...
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Full title
Insulin regulates the activity of forkhead transcription factor Hnf-3beta/Foxa-2 by Akt-mediated phosphorylation and nuclear/cytosolic localization
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TN_cdi_proquest_miscellaneous_75724314
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_75724314
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ISSN
0027-8424
E-ISSN
1091-6490
