A stem cell–like chromatin pattern may predispose tumor suppressor genes to DNA hypermethylation and...
A stem cell–like chromatin pattern may predispose tumor suppressor genes to DNA hypermethylation and heritable silencing
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New York: Nature Publishing Group US
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Language
English
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Publisher
New York: Nature Publishing Group US
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Contents
Adult cancers may derive from stem or early progenitor cells
1
,
2
. Epigenetic modulation of gene expression is essential for normal function of these early cells but is highly abnormal in cancers, which often show aberrant promoter CpG island hypermethylation and transcriptional silencing of tumor suppressor genes and pro-differentiat...
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Full title
A stem cell–like chromatin pattern may predispose tumor suppressor genes to DNA hypermethylation and heritable silencing
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TN_cdi_proquest_miscellaneous_762268729
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_762268729
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ISSN
1061-4036
E-ISSN
1546-1718
DOI
10.1038/ng1972
