Defective tryptophan catabolism underlies inflammation in mouse chronic granulomatous disease
Defective tryptophan catabolism underlies inflammation in mouse chronic granulomatous disease
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Key role for superoxides
In chronic granulomatous disease (CGD), phagocytes lack NADPH oxidase activity and are unable to generate superoxide, making sufferers susceptible to recurrent microbial infections. The precise mechanism involved — and the reasons for exaggerated inflammation in CGD — are unclear. Experiments in genetically engineered CG...
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Defective tryptophan catabolism underlies inflammation in mouse chronic granulomatous disease
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TN_cdi_proquest_miscellaneous_762270360
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_762270360
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ISSN
0028-0836
E-ISSN
1476-4687,1476-4679
DOI
10.1038/nature06471
