Platelet TLR4 activates neutrophil extracellular traps to ensnare bacteria in septic blood
Platelet TLR4 activates neutrophil extracellular traps to ensnare bacteria in septic blood
About this item
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Author / Creator
Clark, Stephen R , Ma, Adrienne C , Tavener, Samantha A , McDonald, Braedon , Goodarzi, Zahra , Kelly, Margaret M , Patel, Kamala D , Chakrabarti, Subhadeep , McAvoy, Erin , Sinclair, Gary D , Keys, Elizabeth M , Allen-Vercoe, Emma , DeVinney, Rebekah , Doig, Christopher J , Green, Francis H Y and Kubes, Paul
Publisher
New York: Nature Publishing Group US
Journal title
Language
English
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Publication information
Publisher
New York: Nature Publishing Group US
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Scope and Contents
Contents
It has been known for many years that neutrophils and platelets participate in the pathogenesis of severe sepsis, but the inter-relationship between these players is completely unknown. We report several cellular events that led to enhanced trapping of bacteria in blood vessels: platelet TLR4 detected TLR4 ligands in blood and induced platelet bind...
Alternative Titles
Full title
Platelet TLR4 activates neutrophil extracellular traps to ensnare bacteria in septic blood
Authors, Artists and Contributors
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Record Identifier
TN_cdi_proquest_miscellaneous_762277694
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_762277694
Other Identifiers
ISSN
1078-8956
E-ISSN
1546-170X
DOI
10.1038/nm1565
