Structural Basis for Selectivity of the Isoquinoline Sulfonamide Family of Protein Kinase Inhibitors
Structural Basis for Selectivity of the Isoquinoline Sulfonamide Family of Protein Kinase Inhibitors
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United States: National Academy of Sciences of the United States of America
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Language
English
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United States: National Academy of Sciences of the United States of America
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Contents
A large family of isoquinoline sulfonamide compounds inhibits protein kinases by competing with adenosine triphosphates (ATP), yet interferes little with the activity of other ATP-using enzymes such as ATPases and adenylate cyclases. One such compound, N-(2-aminoethyl)-5-chloroisoquinoline-8-sulfonamide (CK17), is selective for casein kinase-1 isol...
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Full title
Structural Basis for Selectivity of the Isoquinoline Sulfonamide Family of Protein Kinase Inhibitors
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TN_cdi_proquest_miscellaneous_78127654
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_78127654
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ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.93.13.6308
