Spiroindolones, a Potent Compound Class for the Treatment of Malaria
Spiroindolones, a Potent Compound Class for the Treatment of Malaria
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Author / Creator
Rottmann, Matthias , McNamara, Case , Yeung, Bryan K.S , Lee, Marcus C.S , Zou, Bin , Russell, Bruce , Seitz, Patrick , Plouffe, David M , Dharia, Neekesh V , Tan, Jocelyn , Cohen, Steven B , Spencer, Kathryn R , González-Páez, Gonzalo E , Lakshminarayana, Suresh B , Goh, Anne , Suwanarusk, Rossarin , Jegla, Timothy , Schmitt, Esther K , Beck, Hans-Peter , Brun, Reto , Nosten, Francois , Renia, Laurent , Dartois, Veronique , Keller, Thomas H , Fidock, David A , Winzeler, Elizabeth A and Diagana, Thierry T
Publisher
Washington, DC: American Association for the Advancement of Science
Journal title
Language
English
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Publication information
Publisher
Washington, DC: American Association for the Advancement of Science
Subjects
More information
Scope and Contents
Contents
Recent reports of increased tolerance to artemisinin derivatives--the most recently adopted class of antimalarials--have prompted a need for new treatments. The spirotetrahydro-β-carbolines, or spiroindolones, are potent drugs that kill the blood stages of Plasmodium falciparum and Plasmodium vivax clinical isolates at low nanomolar concentration....
Alternative Titles
Full title
Spiroindolones, a Potent Compound Class for the Treatment of Malaria
Authors, Artists and Contributors
Author / Creator
McNamara, Case
Yeung, Bryan K.S
Lee, Marcus C.S
Zou, Bin
Russell, Bruce
Seitz, Patrick
Plouffe, David M
Dharia, Neekesh V
Tan, Jocelyn
Cohen, Steven B
Spencer, Kathryn R
González-Páez, Gonzalo E
Lakshminarayana, Suresh B
Goh, Anne
Suwanarusk, Rossarin
Jegla, Timothy
Schmitt, Esther K
Beck, Hans-Peter
Brun, Reto
Nosten, Francois
Renia, Laurent
Dartois, Veronique
Keller, Thomas H
Fidock, David A
Winzeler, Elizabeth A
Diagana, Thierry T
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_proquest_miscellaneous_787275674
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_787275674
Other Identifiers
ISSN
0036-8075,1095-9203
E-ISSN
1095-9203
DOI
10.1126/science.1193225
