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ArticlesPeer ReviewedFull Text
A Cryptosporidium PI(4)K inhibitor is a drug candidate for cryptosporidiosis
Author / Creator:Manjunatha, Ujjini H. ; Vinayak, Sumiti ; Zambriski, Jennifer A. ; Chao, Alexander T. ; Sy, Tracy ; Noble, Christian G. ; Bonamy, Ghislain M. C. ; Kondreddi, Ravinder R. ; Zou, Bin ; Gedeck, Peter ; Brooks, Carrie F. ; Herbert, Gillian T. ; Sateriale, Adam ; Tandel, Jayesh ; Noh, Susan ; Lakshminarayana, Suresh B. ; Lim, Siau H. ; Goodman, Laura B. ; Bodenreider, Christophe ; Feng, Gu ; Zhang, Lijun ; Blasco, Francesca ; Wagner, Juergen ; Leong, F. Joel ; Striepen, Boris ; Diagana, Thierry T.
Publisher:London: Nature Publishing Group UK
Journal title:Nature (London), 2017-06, Vol.546 (7658), p.376-380
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ArticlesPeer ReviewedFull Text
Spiroindolones, a Potent Compound Class for the Treatment of Malaria
Author / Creator:Rottmann, Matthias ; McNamara, Case ; Yeung, Bryan K.S ; Lee, Marcus C.S ; Zou, Bin ; Russell, Bruce ; Seitz, Patrick ; Plouffe, David M ; Dharia, Neekesh V ; Tan, Jocelyn ; Cohen, Steven B ; Spencer, Kathryn R ; González-Páez, Gonzalo E ; Lakshminarayana, Suresh B ; Goh, Anne ; Suwanarusk, Rossarin ; Jegla, Timothy ; Schmitt, Esther K ; Beck, Hans-Peter ; Brun, Reto ; Nosten, Francois ; Renia, Laurent ; Dartois, Veronique ; Keller, Thomas H ; Fidock, David A ; Winzeler, Elizabeth A ; Diagana, Thierry T
Publisher:Washington, DC: American Association for the Advancement of Science
Journal title:Science (American Association for the Advancement of Science), 2010-09, Vol.329 (5996), p.1175-1180
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ArticlesPeer ReviewedFull Text
adenosine nucleoside inhibitor of dengue virus
Author / Creator:Yin, Zheng ; Chen, Yen-Liang ; Schul, Wouter ; Wang, Qing-Yin ; Gu, Feng ; Duraiswamy, Jeyaraj ; Kondreddi, Ravinder Reddy ; Niyomrattanakit, Pornwaratt ; Lakshminarayana, Suresh B ; Goh, Anne ; Xu, Hao Ying ; Liu, Wei ; Liu, Boping ; Lim, Joanne Y.H ; Ng, Chuan Young ; Qing, Min ; Lim, Chin Chin ; Yip, Andy ; Wang, Gang ; Chan, Wai Ling ; Tan, Hui Pen ; Lin, Kai ; Zhang, Bo ; Zou, Gang ; Bernard, Kristen A ; Garrett, Christine ; Beltz, Karen ; Dong, Min ; Weaver, Margaret ; He, Handan ; Pichota, Arkadius ; Dartois, Veronique ; Keller, Thomas H ; Shi, Pei-Yong
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2009-12, Vol.106 (48), p.20435-20439
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ArticlesPeer ReviewedFull Text
Pharmacokinetics-Pharmacodynamics Analysis of Bicyclic 4-Nitroimidazole Analogs in a Murine Model of Tuberculosis
Author / Creator:Lakshminarayana, Suresh B. ; Boshoff, Helena I. M. ; Cherian, Joseph ; Ravindran, Sindhu ; Goh, Anne ; Jiricek, Jan ; Nanjundappa, Mahesh ; Nayyar, Amit ; Gurumurthy, Meera ; Singh, Ramandeep ; Dick, Thomas ; Blasco, Francesca ; Barry, Clifton E. ; Ho, Paul C. ; Manjunatha, Ujjini H.
Publisher:United States: Public Library of Science
Journal title:PloS one, 2014-08, Vol.9 (8), p.e105222
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ArticlesPeer ReviewedFull Text
Anti-trypanosomal proteasome inhibitors cure hemolymphatic and meningoencephalic murine infection models of African trypanosomiasis
Author / Creator:Rao, Srinivasa P S ; Lakshminarayana, Suresh B ; Jiricek, Jan ; Kaiser, Marcel ; Ritchie, Ryan ; Myburgh, Elmarie ; Supek, Frantisek ; Tuntland, Tove ; Nagle, Advait ; Molteni, Valentina ; Mäser, Pascal ; Mottram, Jeremy C ; Barrett, Michael P ; Diagana, Thierry T
Publisher:Switzerland: MDPI AG
Journal title:Tropical medicine and infectious disease, 2020-03, Vol.5 (1), p.1-14
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ArticlesPeer ReviewedFull Text
A chemical genetic screen in Mycobacterium tuberculosis identifies carbon-source-dependent growth inhibitors devoid of in vivo efficacy
Author / Creator:Pethe, Kevin ; Sequeira, Patricia C. ; Agarwalla, Sanjay ; Rhee, Kyu ; Kuhen, Kelli ; Phong, Wai Yee ; Patel, Viral ; Beer, David ; Walker, John R. ; Duraiswamy, Jeyaraj ; Jiricek, Jan ; Keller, Thomas H. ; Chatterjee, Arnab ; Tan, Mai Ping ; Ujjini, Manjunatha ; Rao, Srinivasa P.S. ; Camacho, Luis ; Bifani, Pablo ; Mak, Puiying A. ; Ma, Ida ; Barnes, S. Whitney ; Chen, Zhong ; Plouffe, David ; Thayalan, Pamela ; Ng, Seow Hwee ; Au, Melvin ; Lee, Boon Heng ; Tan, Bee Huat ; Ravindran, Sindhu ; Nanjundappa, Mahesh ; Lin, Xiuhua ; Goh, Anne ; Lakshminarayana, Suresh B. ; Shoen, Carolyn ; Cynamon, Michael ; Kreiswirth, Barry ; Dartois, Veronique ; Peters, Eric C. ; Glynne, Richard ; Brenner, Sydney ; Dick, Thomas
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2010-08, Vol.1 (1), p.57-8, Article 57
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ArticlesPeer ReviewedFull Text
Targeting the trypanosome kinetochore with CLK1 protein kinase inhibitors
Author / Creator:Saldivia, Manuel ; Fang, Eric ; Ma, Xiaolei ; Myburgh, Elmarie ; Carnielli, Juliana B. T. ; Bower-Lepts, Christopher ; Brown, Elaine ; Ritchie, Ryan ; Lakshminarayana, Suresh B. ; Chen, Yen-Liang ; Patra, Debjani ; Ornelas, Elizabeth ; Koh, Hazel X. Y. ; Williams, Sarah L. ; Supek, Frantisek ; Paape, Daniel ; McCulloch, Richard ; Kaiser, Marcel ; Barrett, Michael P. ; Jiricek, Jan ; Diagana, Thierry T. ; Mottram, Jeremy C. ; Rao, Srinivasa P. S.
Publisher:London: Nature Publishing Group UK
Journal title:Nature microbiology, 2020-10, Vol.5 (10), p.1207-1216
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ArticlesPeer ReviewedFull Text
Differences in the pharmacokinetics of currently approved antimalarial drugs in uncomplicated malaria patients compared to healthy subjects
Author / Creator:Jain, Jay Prakash ; Lakshminarayana, Suresh B ; Lefèvre, Gilbert ; Sivasubramanian, Rama ; Blasco, Francesca ; Sunkara, Gangadhar
Publisher:London: BioMed Central
Journal title:Malaria journal, 2012-10, Vol.11 (S1), p.P118-P118, Article P118
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ArticlesPeer ReviewedFull Text
A Cryptosporidium PIK inhibitor is a drug candidate for cryptosporidiosis
Author / Creator:Manjunatha, Ujjini H ; Vinayak, Sumiti ; Zambriski, Jennifer A ; Chao, Alexander T ; Sy, Tracy ; Noble, Christian G ; Bonamy, Ghislain M. C ; Kondreddi, Ravinder R ; Zou, Bin ; Gedeck, Peter ; Brooks, Carrie F ; Herbert, Gillian T ; Sateriale, Adam ; Tandel, Jayesh ; Noh, Susan ; Lakshminarayana, Suresh B ; Lim, Siau H ; Goodman, Laura B ; Bodenreider, Christophe ; Feng, Gu ; Zhang, Lijun ; Blasco, Francesca ; Wagner, Juergen ; Leong, F. Joel ; Striepen, Boris ; Diagana, Thierry T
Publisher:Nature Publishing Group
Journal title:Nature (London), 2017-06, Vol.546 (7658), p.376
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ArticlesPeer ReviewedFull Text
Pharmacokinetics-Pharmacodynamics Analysis of Bicyclic 4-Nitroimidazole Analogs in a Murine Model of Tuberculosis: e105222
Author / Creator:Lakshminarayana, Suresh B ; Boshoff, Helena IM ; Cherian, Joseph ; Ravindran, Sindhu ; Goh, Anne ; Jiricek, Jan ; Nanjundappa, Mahesh ; Nayyar, Amit ; Gurumurthy, Meera ; Singh, Ramandeep
Journal title:PloS one, 2014-08, Vol.9 (8)
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ArticlesPeer ReviewedFull Text
Spiroindolones, a new and potent chemotype for the treatment of malaria
Author / Creator:Rottmann, Matthias ; McNamara, Case ; Yeung, Bryan K. S. ; Lee, Marcus C. S. ; Zou, Bin ; Russell, Bruce ; Seitz, Patrick ; Plouffe, David M. ; Dharia, Neekesh V. ; Tan, Jocelyn ; Cohen, Steven B. ; Spencer, Kathryn R. ; González-Páez, Gonzalo E. ; Lakshminarayana, Suresh B. ; Goh, Anne ; Suwanarusk, Rossarin ; Jegla, Tim ; Schmitt, Esther K. ; Beck, Hans-Peter ; Brun, Reto ; Nosten, Francois ; Renia, Laurent ; Dartois, Veronique ; Keller, Thomas H. ; Fidock, David A. ; Winzeler, Elizabeth A. ; Diagana, Thierry T.
Journal title:Science (American Association for the Advancement of Science), 2010-09, Vol.329 (5996), p.1175-1180
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A Cryptosporidium PI(4)K inhibitor is a drug candidate for cryptosporidiosis

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Spiroindolones, a Potent Compound Class for the Treatment of Malaria

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adenosine nucleoside inhibitor of dengue virus

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Pharmacokinetics-Pharmacodynamics Analysis of Bicyclic 4-Nitroimidazole Analogs in a Murine Model of Tuberculosis

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Anti-trypanosomal proteasome inhibitors cure hemolymphatic and meningoencephalic murine infection models of African trypanosomiasis

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A chemical genetic screen in Mycobacterium tuberculosis identifies carbon-source-dependent growth inhibitors devoid of in vivo efficacy

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Targeting the trypanosome kinetochore with CLK1 protein kinase inhibitors

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Differences in the pharmacokinetics of currently approved antimalarial drugs in uncomplicated malaria patients compared to healthy subjects

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A Cryptosporidium PIK inhibitor is a drug candidate for cryptosporidiosis

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Pharmacokinetics-Pharmacodynamics Analysis of Bicyclic 4-Nitroimidazole Analogs in a Murine Model of Tuberculosis: e105222

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Spiroindolones, a new and potent chemotype for the treatment of malaria

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