A Transmembrane Form of the Prion Protein in Neurodegenerative Disease
A Transmembrane Form of the Prion Protein in Neurodegenerative Disease
About this item
Full title
Author / Creator
Publisher
Washington, DC: American Society for the Advancement of Science
Journal title
Language
English
Formats
Publication information
Publisher
Washington, DC: American Society for the Advancement of Science
Subjects
More information
Scope and Contents
Contents
At the endoplasmic reticulum membrane, the prion protein (PrP) can be synthesized in several topological forms. The role of these different forms was explored with transgenic mice expressing PrP mutations that alter the relative ratios of the topological forms. Expression of a particular transmembrane form (termed $^{Ctm}$PrP) produced neurodegener...
Alternative Titles
Full title
A Transmembrane Form of the Prion Protein in Neurodegenerative Disease
Authors, Artists and Contributors
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_proquest_miscellaneous_79674009
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_79674009
Other Identifiers
ISSN
0036-8075
E-ISSN
1095-9203
DOI
10.1126/science.279.5352.827
