Molecular determinants of resistance to antiandrogen therapy
Molecular determinants of resistance to antiandrogen therapy
About this item
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Publisher
New York: Nature Publishing Group US
Journal title
Language
English
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Publication information
Publisher
New York: Nature Publishing Group US
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Contents
Using microarray-based profiling of isogenic prostate cancer xenograft models, we found that a modest increase in androgen receptor mRNA was the only change consistently associated with the development of resistance to antiandrogen therapy. This increase in androgen receptor mRNA and protein was both necessary and sufficient to convert prostate can...
Alternative Titles
Full title
Molecular determinants of resistance to antiandrogen therapy
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TN_cdi_proquest_miscellaneous_80078752
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_80078752
Other Identifiers
ISSN
1078-8956
E-ISSN
1546-170X
DOI
10.1038/nm972
