Phosphatidylinositol-3-OH kinase/AKT and survivin pathways as critical targets for geranylgeranyltra...
Phosphatidylinositol-3-OH kinase/AKT and survivin pathways as critical targets for geranylgeranyltransferase I inhibitor-induced apoptosis
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Geranylgeranyltransferase I inhibitors (GGTIs) represent a new class of anticancer drugs. However, the mechanism by which GGTIs inhibit tumor cell growth is still unclear. Here, we demonstrate that GGTI-298 and GGTI-2166 induce apoptosis in both cisplatin-sensitive and -resistant human ovarian epithelial cancer cells by inhibition of PI3K/AKT and s...
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Phosphatidylinositol-3-OH kinase/AKT and survivin pathways as critical targets for geranylgeranyltransferase I inhibitor-induced apoptosis
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TN_cdi_proquest_miscellaneous_80115259
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_80115259
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ISSN
0950-9232
E-ISSN
1476-5594
DOI
10.1038/sj.onc.1207171
