Diarylquinolines target subunit c of mycobacterial ATP synthase
Diarylquinolines target subunit c of mycobacterial ATP synthase
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New York: Nature Publishing Group US
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Language
English
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Publisher
New York: Nature Publishing Group US
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Contents
The diarylquinoline R207910 (TMC207) is a promising candidate in clinical development for the treatment of tuberculosis. Though R207910-resistant mycobacteria bear mutations in ATP synthase, the compound's precise target is not known. Here we establish by genetic, biochemical and binding assays that the oligomeric subunit c (AtpE) of ATP synthase i...
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Full title
Diarylquinolines target subunit c of mycobacterial ATP synthase
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TN_cdi_proquest_miscellaneous_807266255
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_807266255
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ISSN
1552-4450
E-ISSN
1552-4469
DOI
10.1038/nchembio884
