NES consensus redefined by structures of PKI-type and Rev-type nuclear export signals bound to CRM1
NES consensus redefined by structures of PKI-type and Rev-type nuclear export signals bound to CRM1
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Publisher
New York: Nature Publishing Group US
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Language
English
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Publisher
New York: Nature Publishing Group US
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Contents
How a variety of nuclear export signals (NESs) are recognized by their receptor CRM1 is now examined by crystallography, NMR spectroscopy, biochemistry and cellular approaches. The work reveals that the different NES peptides adopt different conformations to fit into five rigid hydrophobic binding pockets on CRM1, and redefines an NES consensus.
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Full title
NES consensus redefined by structures of PKI-type and Rev-type nuclear export signals bound to CRM1
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TN_cdi_proquest_miscellaneous_808459710
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_808459710
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ISSN
1545-9993
E-ISSN
1545-9985
DOI
10.1038/nsmb.1931
