Smad7 binds to the adaptors TAB2 and TAB3 to block recruitment of the kinase TAK1 to the adaptor TRA...
Smad7 binds to the adaptors TAB2 and TAB3 to block recruitment of the kinase TAK1 to the adaptor TRAF2
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Publisher
New York: Nature Publishing Group US
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English
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New York: Nature Publishing Group US
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Transforming growth factor-β1 (TGF-β1) regulates inflammation and can inhibit activation of the transcription factor NF-κB in certain cell types. Here we show that the TGF-β-induced signaling protein Smad7 bound to TAB2 and TAB3, which are adaptors that link the kinase TAK1 to 'upstream' regulators in the proinflammatory tumor necrosis factor (TNF)...
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Full title
Smad7 binds to the adaptors TAB2 and TAB3 to block recruitment of the kinase TAK1 to the adaptor TRAF2
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TN_cdi_proquest_miscellaneous_851461531
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_851461531
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ISSN
1529-2908
E-ISSN
1529-2916,1365-2567
DOI
10.1038/ni1451
