Frequent concomitant inactivation of miR-34a and miR-34b/c by CpG methylation in colorectal, pancrea...
Frequent concomitant inactivation of miR-34a and miR-34b/c by CpG methylation in colorectal, pancreatic, mammary, ovarian, urothelial, and renal cell carcinomas and soft tissue sarcomas
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Publisher
Berlin/Heidelberg: Springer-Verlag
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Language
English
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Publisher
Berlin/Heidelberg: Springer-Verlag
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Contents
The microRNA encoding genes
miR-34a
and
miR-34b/c
represent direct p53 target genes and possess tumor suppressive properties as they mediate apoptosis, cell cycle arrest, and senescence. We previously reported that the
miR-34a
gene is subject to epigenetic inactivation by CpG methylation of its promoter region in primary prostate...
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Full title
Frequent concomitant inactivation of miR-34a and miR-34b/c by CpG methylation in colorectal, pancreatic, mammary, ovarian, urothelial, and renal cell carcinomas and soft tissue sarcomas
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TN_cdi_proquest_miscellaneous_853993314
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_853993314
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ISSN
0945-6317
E-ISSN
1432-2307
DOI
10.1007/s00428-010-1030-5
