Early mitochondrial calcium defects in Huntington's disease are a direct effect of polyglutamines
Early mitochondrial calcium defects in Huntington's disease are a direct effect of polyglutamines
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New York: Nature Publishing Group US
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Language
English
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Publisher
New York: Nature Publishing Group US
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Huntington's disease (HD) is caused by an expansion of exonic CAG triplet repeats in the gene encoding huntingtin protein (Htt), but the mechanisms by which this mutant protein causes neurodegeneration remain unknown. Here we show that lymphoblast mitochondria from patients with HD have a lower membrane potential and depolarize at lower calcium loa...
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Full title
Early mitochondrial calcium defects in Huntington's disease are a direct effect of polyglutamines
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TN_cdi_proquest_miscellaneous_856763292
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_856763292
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ISSN
1097-6256
E-ISSN
1546-1726
DOI
10.1038/nn884
