Molecular basis of purine-rich RNA recognition by the human SR-like protein Tra2-β1
Molecular basis of purine-rich RNA recognition by the human SR-like protein Tra2-β1
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New York: Nature Publishing Group US
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English
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New York: Nature Publishing Group US
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Contents
Tra2-β1 is a splicing factor involved in facilitating SMN2 exon 7 splicing. Exon 7 inclusion prevents SMN2 from rescuing the SMN1 deletion, a situation linked to spinal muscular atrophy. The structure of Tra2-β1 in complex with an RNA target is now presented, giving insight into purine recognition by an unusual RNA binding mode.
Tra2-β1 is a uni...
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Full title
Molecular basis of purine-rich RNA recognition by the human SR-like protein Tra2-β1
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TN_cdi_proquest_miscellaneous_860882109
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_860882109
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ISSN
1545-9993
E-ISSN
1545-9985
DOI
10.1038/nsmb.2001
