α-Mannosidase 2C1 attenuates PTEN function in prostate cancer cells
α-Mannosidase 2C1 attenuates PTEN function in prostate cancer cells
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London: Nature Publishing Group UK
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Language
English
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London: Nature Publishing Group UK
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Contents
PTEN dephosphorylates the 3-position phosphate of phosphatidylinositol 3,4,5 triphosphate (PIP
3
), thereby inhibiting AKT activation. Although attenuation of PTEN function has a major role in tumourigenesis, the underlying mechanisms remain unclear. Here we show that α-mannosidase 2C1 (MAN2C1) inhibits PTEN function in prostate cancer (PC) c...
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Full title
α-Mannosidase 2C1 attenuates PTEN function in prostate cancer cells
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TN_cdi_proquest_miscellaneous_866046923
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_866046923
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/ncomms1309
