DNA glycosylase encoded by MUTYH functions as a molecular switch for programmed cell death under oxi...
DNA glycosylase encoded by MUTYH functions as a molecular switch for programmed cell death under oxidative stress to suppress tumorigenesis
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Publisher
Oxford, UK: Blackwell Publishing Ltd
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Language
English
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Publisher
Oxford, UK: Blackwell Publishing Ltd
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Contents
8‐oxoguanine is a major base lesion in DNA or in nucleotides caused by oxidative stress, and is highly mutagenic because it can pair with adenine as well as cytosine. Adenine DNA glycosylase, encoded by the human mutY homolog gene, MUTYH, excises adenine in the nascent strand when inserted opposite 8‐oxoguanine in template DNA, and thus suppresses...
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Full title
DNA glycosylase encoded by MUTYH functions as a molecular switch for programmed cell death under oxidative stress to suppress tumorigenesis
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TN_cdi_proquest_miscellaneous_904469535
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_904469535
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ISSN
1347-9032
E-ISSN
1349-7006
DOI
10.1111/j.1349-7006.2011.01869.x
