Mechanism of RAD51-Dependent DNA Interstrand Cross-Link Repair
Mechanism of RAD51-Dependent DNA Interstrand Cross-Link Repair
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Publisher
Washington, DC: American Association for the Advancement of Science
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Language
English
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Washington, DC: American Association for the Advancement of Science
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Scope and Contents
Contents
DNA interstrand cross-links (ICLs) are toxic DNA lesions whose repair in S phase of eukaryotic cells is incompletely understood. In Xenopus egg extracts, ICL repair is initiated when two replication forks converge on the lesion. Dual incisions then create a DNA double-strand break (DSB) in one sister chromatid, whereas lesion bypass restores the ot...
Alternative Titles
Full title
Mechanism of RAD51-Dependent DNA Interstrand Cross-Link Repair
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Author / Creator
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TN_cdi_proquest_miscellaneous_904489595
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_904489595
Other Identifiers
ISSN
0036-8075
E-ISSN
1095-9203
DOI
10.1126/science.1204258
