Biosynthesis of the immunosuppressants FK506, FK520, and rapamycin involves a previously undescribed...
Biosynthesis of the immunosuppressants FK506, FK520, and rapamycin involves a previously undescribed family of enzymes acting on chorismate
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Author / Creator
Andexer, Jennifer N , Kendrew, Steven G , Nur-e-Alam, Mohammad , Lazos, Orestis , Foster, Teresa A , Zimmermann, Anna-Sophie , Warneck, Tony D , Suthar, Dipen , Coates, Nigel J , Koehn, Frank E , Skotnicki, Jerauld S , Carter, Guy T , Gregory, Matthew A , Martin, Christine J , Moss, Steven J , Leadlay, Peter F and Wilkinson, Barrie
Publisher
United States: National Academy of Sciences
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Language
English
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Publisher
United States: National Academy of Sciences
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Scope and Contents
Contents
The macrocyclic polyketides FK506, FK520, and rapamycin are potent immunosuppressants that prevent T-cell proliferation through initial binding to the immunophilin FKBP12. Analogs of these molecules are of considerable interest as therapeutics in both metastatic and inflammatory disease. For these polyketides the starter unit for chain assembly is...
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Full title
Biosynthesis of the immunosuppressants FK506, FK520, and rapamycin involves a previously undescribed family of enzymes acting on chorismate
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Record Identifier
TN_cdi_proquest_miscellaneous_907161197
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_907161197
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1015773108
