Variants at 6q21 implicate PRDM1 in the etiology of therapy-induced second malignancies after Hodgki...
Variants at 6q21 implicate PRDM1 in the etiology of therapy-induced second malignancies after Hodgkin's lymphoma
About this item
Full title
Author / Creator
Best, Timothy , Li, Dalin , Skol, Andrew D , Kirchhoff, Tomas , Jackson, Sarah A , Yasui, Yutaka , Bhatia, Smita , Strong, Louise C , Domchek, Susan M , Nathanson, Katherine L , Olopade, Olufunmilayo I , Huang, R Stephanie , Mack, Thomas M , Conti, David V , Offit, Kenneth , Cozen, Wendy , Robison, Leslie L and Onel, Kenan
Publisher
New York: Nature Publishing Group US
Journal title
Language
English
Formats
Publication information
Publisher
New York: Nature Publishing Group US
Subjects
More information
Scope and Contents
Contents
Patients undergoing radiation treatment for Hodgkins's lymphoma are at increased risk of developing secondary malignancies with time. This genome-wide analysis identifies genetic polymorphisms associated with increased risk of secondary malignancies in treated children. The risk alleles result in decreased radiation-mediated induction of PRDM1, a t...
Alternative Titles
Full title
Variants at 6q21 implicate PRDM1 in the etiology of therapy-induced second malignancies after Hodgkin's lymphoma
Authors, Artists and Contributors
Author / Creator
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_proquest_miscellaneous_907174433
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_907174433
Other Identifiers
ISSN
1078-8956
E-ISSN
1546-170X
DOI
10.1038/nm.2407
