Structures of cytochrome P450 17A1 with prostate cancer drugs abiraterone and TOK-001
Structures of cytochrome P450 17A1 with prostate cancer drugs abiraterone and TOK-001
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Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Scope and Contents
Contents
The structures of CYP17A1 with steroid inhibitors abiraterone or TOK-001 provide a better understanding of the enzyme’s catalytic capabilities and inhibition, and hence assist in understanding steroidogenic diseases and designing drugs to improve the treatment of prostate and other steroid-responsive cancers.
Cytochrome P450 17A1 as a drug targe...
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Full title
Structures of cytochrome P450 17A1 with prostate cancer drugs abiraterone and TOK-001
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TN_cdi_proquest_miscellaneous_919945444
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_919945444
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ISSN
0028-0836
E-ISSN
1476-4687
DOI
10.1038/nature10743
