Mitochondrial outer-membrane protein FUNDC1 mediates hypoxia-induced mitophagy in mammalian cells
Mitochondrial outer-membrane protein FUNDC1 mediates hypoxia-induced mitophagy in mammalian cells
About this item
Full title
Author / Creator
Liu, Lei , Feng, Du , Chen, Guo , Chen, Ming , Zheng, Qiaoxia , Song, Pingping , Ma, Qi , Zhu, Chongzhuo , Wang, Rui , Qi, Wanjun , Huang, Lei , Xue, Peng , Li, Baowei , Wang, Xiaohui , Jin, Haijing , Wang, Jun , Yang, Fuquan , Liu, Pingsheng , Zhu, Yushan , Sui, Senfang and Chen, Quan
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Damaged mitochondria can be removed by mitophagy, but how this organelle is recognized by the autophagy machinery is unclear. Chen and colleagues show that FUNDC1, an integral mitochondrial outer membrane protein, interacts with light chain 3 (LC3) and is essential for hypoxia-induced mitophagy.
Accumulating evidence has shown that dysfunctional...
Alternative Titles
Full title
Mitochondrial outer-membrane protein FUNDC1 mediates hypoxia-induced mitophagy in mammalian cells
Authors, Artists and Contributors
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_proquest_miscellaneous_919950962
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_919950962
Other Identifiers
ISSN
1465-7392
E-ISSN
1476-4679
DOI
10.1038/ncb2422
