Identification of a mutation in the extracellular domain of the Epidermal Growth Factor Receptor con...
Identification of a mutation in the extracellular domain of the Epidermal Growth Factor Receptor conferring cetuximab resistance in colorectal cancer
About this item
Full title
Author / Creator
Montagut, Clara , Dalmases, Alba , Bellosillo, Beatriz , Crespo, Marta , Pairet, Silvia , Iglesias, Mar , Salido, Marta , Gallen, Manuel , Marsters, Scot , Tsai, Siao Ping , Minoche, André , Seshagiri, Somasekar , Serrano, Sergi , Himmelbauer, Heinz , Bellmunt, Joaquim , Rovira, Ana , Settleman, Jeff , Bosch, Francesc and Albanell, Joan
Publisher
New York: Nature Publishing Group US
Journal title
Language
English
Formats
Publication information
Publisher
New York: Nature Publishing Group US
Subjects
More information
Scope and Contents
Contents
By modeling acquired resistance to the EGFR antibody cetuximab in metastatic colorectal cancer, the authors identify a new mutation in the ectodomain of the receptor. The mutation is present in patient tumors after cetuximab therapy, confirming that it represents a clinically-relevant mechanism for therapy resistance. Moreover, the mutation does no...
Alternative Titles
Full title
Identification of a mutation in the extracellular domain of the Epidermal Growth Factor Receptor conferring cetuximab resistance in colorectal cancer
Authors, Artists and Contributors
Author / Creator
Dalmases, Alba
Bellosillo, Beatriz
Crespo, Marta
Pairet, Silvia
Iglesias, Mar
Salido, Marta
Gallen, Manuel
Marsters, Scot
Tsai, Siao Ping
Minoche, André
Seshagiri, Somasekar
Serrano, Sergi
Himmelbauer, Heinz
Bellmunt, Joaquim
Rovira, Ana
Settleman, Jeff
Bosch, Francesc
Albanell, Joan
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_proquest_miscellaneous_920368557
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_920368557
Other Identifiers
ISSN
1078-8956
E-ISSN
1546-170X
DOI
10.1038/nm.2609
