Driver mutations in histone H3.3 and chromatin remodelling genes in paediatric glioblastoma
Driver mutations in histone H3.3 and chromatin remodelling genes in paediatric glioblastoma
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Author / Creator
Schwartzentruber, Jeremy , Korshunov, Andrey , Liu, Xiao-Yang , Jones, David T. W. , Pfaff, Elke , Jacob, Karine , Sturm, Dominik , Fontebasso, Adam M. , Quang, Dong-Anh Khuong , Tönjes, Martje , Hovestadt, Volker , Albrecht, Steffen , Kool, Marcel , Nantel, Andre , Konermann, Carolin , Lindroth, Anders , Jäger, Natalie , Rausch, Tobias , Ryzhova, Marina , Korbel, Jan O. , Hielscher, Thomas , Hauser, Peter , Garami, Miklos , Klekner, Almos , Bognar, Laszlo , Ebinger, Martin , Schuhmann, Martin U. , Scheurlen, Wolfram , Pekrun, Arnulf , Frühwald, Michael C. , Roggendorf, Wolfgang , Kramm, Christoph , Dürken, Matthias , Atkinson, Jeffrey , Lepage, Pierre , Montpetit, Alexandre , Zakrzewska, Magdalena , Zakrzewski, Krzystof , Liberski, Pawel P. , Dong, Zhifeng , Siegel, Peter , Kulozik, Andreas E. , Zapatka, Marc , Guha, Abhijit , Malkin, David , Felsberg, Jörg , Reifenberger, Guido , von Deimling, Andreas , Ichimura, Koichi , Collins, V. Peter , Witt, Hendrik , Milde, Till , Witt, Olaf , Zhang, Cindy , Castelo-Branco, Pedro , Lichter, Peter , Faury, Damien , Tabori, Uri , Plass, Christoph , Majewski, Jacek , Pfister, Stefan M. and Jabado, Nada
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publisher
London: Nature Publishing Group UK
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Scope and Contents
Contents
Recurrent histone mutations are linked to paediatric glioblastoma multiforme, an aggressive type of brain tumour.
Drug targets in glioblastoma
Exome sequencing of 48 childhood glioblastoma samples has identified somatic mutations in the H3.3-ATRX-DAXX chromatin remodelling pathway in 44% of tumours. Mutations in H3F3A, which encodes the repli...
Alternative Titles
Full title
Driver mutations in histone H3.3 and chromatin remodelling genes in paediatric glioblastoma
Authors, Artists and Contributors
Author / Creator
Korshunov, Andrey
Liu, Xiao-Yang
Jones, David T. W.
Pfaff, Elke
Jacob, Karine
Sturm, Dominik
Fontebasso, Adam M.
Quang, Dong-Anh Khuong
Tönjes, Martje
Hovestadt, Volker
Albrecht, Steffen
Kool, Marcel
Nantel, Andre
Konermann, Carolin
Lindroth, Anders
Jäger, Natalie
Rausch, Tobias
Ryzhova, Marina
Korbel, Jan O.
Hielscher, Thomas
Hauser, Peter
Garami, Miklos
Klekner, Almos
Bognar, Laszlo
Ebinger, Martin
Schuhmann, Martin U.
Scheurlen, Wolfram
Pekrun, Arnulf
Frühwald, Michael C.
Roggendorf, Wolfgang
Kramm, Christoph
Dürken, Matthias
Atkinson, Jeffrey
Lepage, Pierre
Montpetit, Alexandre
Zakrzewska, Magdalena
Zakrzewski, Krzystof
Liberski, Pawel P.
Dong, Zhifeng
Siegel, Peter
Kulozik, Andreas E.
Zapatka, Marc
Guha, Abhijit
Malkin, David
Felsberg, Jörg
Reifenberger, Guido
von Deimling, Andreas
Ichimura, Koichi
Collins, V. Peter
Witt, Hendrik
Milde, Till
Witt, Olaf
Zhang, Cindy
Castelo-Branco, Pedro
Lichter, Peter
Faury, Damien
Tabori, Uri
Plass, Christoph
Majewski, Jacek
Pfister, Stefan M.
Jabado, Nada
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_proquest_miscellaneous_921140599
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_921140599
Other Identifiers
ISSN
0028-0836,1476-4687
E-ISSN
1476-4687
DOI
10.1038/nature10833
