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Newsletter articlesFull Text
INTERNATIONAL PATENT: DEUTSCHES KREBSFORSCHUNGSZENTRUM STIFTUNG DES OFFENTLICHEN RECHTS, UNIVERSITAT HEIDELBERG, SILL, MARTIN, PFISTER, STEFAN, JONES, DAVID, VON DEIMLING, ANDREAS, CAPPER, DAVID, HOVE...
Publisher:Washington, D.C: HT Digital Streams Limited
Journal title:US Fed News Service, Including US State News, 2023
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ArticlesPeer ReviewedFull Text
Machine learning workflows to estimate class probabilities for precision cancer diagnostics on DNA methylation microarray data
Author / Creator:Maros, Máté E. ; Capper, David ; Jones, David T. W. ; Hovestadt, Volker ; von Deimling, Andreas ; Pfister, Stefan M. ; Benner, Axel ; Zucknick, Manuela ; Sill, Martin
Publisher:London: Nature Publishing Group UK
Journal title:Nature protocols, 2020-02, Vol.15 (2), p.479-512
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ArticlesPeer ReviewedFull Text
Medulloblastomics revisited: biological and clinical insights from thousands of patients
Author / Creator:Hovestadt, Volker ; Ayrault, Olivier ; Swartling, Fredrik J. ; Robinson, Giles W. ; Pfister, Stefan M. ; Northcott, Paul A.
Publisher:London: Nature Publishing Group UK
Journal title:Nature reviews. Cancer, 2020-01, Vol.20 (1), p.42-56
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ArticlesPeer ReviewedFull Text
Single-cell lineage analysis reveals genetic and epigenetic interplay in glioblastoma drug resistance
Author / Creator:Eyler, Christine E. ; Matsunaga, Hironori ; Hovestadt, Volker ; Vantine, Samantha J. ; van Galen, Peter ; Bernstein, Bradley E.
Publisher:England: BioMed Central Ltd
Journal title:Genome Biology, 2020-07, Vol.21 (1), p.174-174, Article 174
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ArticlesPeer ReviewedFull Text
Tagmentation-based whole-genome bisulfite sequencing
Author / Creator:Wang, Qi ; Gu, Lei ; Adey, Andrew ; Radlwimmer, Bernhard ; Wang, Wei ; Hovestadt, Volker ; Bähr, Marion ; Wolf, Stephan ; Shendure, Jay ; Eils, Roland ; Plass, Christoph ; Weichenhan, Dieter
Publisher:London: Nature Publishing Group UK
Journal title:Nature protocols, 2013-10, Vol.8 (10), p.2022-2032
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ArticlesPeer ReviewedFull Text
Practical implementation of DNA methylation and copy-number-based CNS tumor diagnostics: the Heidelberg experience
Author / Creator:Capper, David ; Stichel, Damian ; Sahm, Felix ; Jones, David T. W. ; Schrimpf, Daniel ; Sill, Martin ; Schmid, Simone ; Hovestadt, Volker ; Reuss, David E. ; Koelsche, Christian ; Reinhardt, Annekathrin ; Wefers, Annika K. ; Huang, Kristin ; Sievers, Philipp ; Ebrahimi, Azadeh ; Schöler, Anne ; Teichmann, Daniel ; Koch, Arend ; Hänggi, Daniel ; Unterberg, Andreas ; Platten, Michael ; Wick, Wolfgang ; Witt, Olaf ; Milde, Till ; Korshunov, Andrey ; Pfister, Stefan M. ; von Deimling, Andreas
Publisher:Berlin/Heidelberg: Springer Berlin Heidelberg
Journal title:Acta neuropathologica, 2018-08, Vol.136 (2), p.181-210
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ArticlesPeer ReviewedFull Text
Second-generation molecular subgrouping of medulloblastoma: an international meta-analysis of Group 3 and Group 4 subtypes
Author / Creator:Sharma, Tanvi ; Schwalbe, Edward C. ; Williamson, Daniel ; Sill, Martin ; Hovestadt, Volker ; Mynarek, Martin ; Rutkowski, Stefan ; Robinson, Giles W. ; Gajjar, Amar ; Cavalli, Florence ; Ramaswamy, Vijay ; Taylor, Michael D. ; Lindsey, Janet C. ; Hill, Rebecca M. ; Jäger, Natalie ; Korshunov, Andrey ; Hicks, Debbie ; Bailey, Simon ; Kool, Marcel ; Chavez, Lukas ; Northcott, Paul A. ; Pfister, Stefan M. ; Clifford, Steven C.
Publisher:Berlin/Heidelberg: Springer Berlin Heidelberg
Journal title:Acta neuropathologica, 2019-08, Vol.138 (2), p.309-326
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ArticlesPeer ReviewedFull Text
IDH mutant diffuse and anaplastic astrocytomas have similar age at presentation and little difference in survival: a grading problem for WHO
Author / Creator:Reuss, David E. ; Mamatjan, Yasin ; Schrimpf, Daniel ; Capper, David ; Hovestadt, Volker ; Kratz, Annekathrin ; Sahm, Felix ; Koelsche, Christian ; Korshunov, Andrey ; Olar, Adriana ; Hartmann, Christian ; Reijneveld, Jaap C. ; Wesseling, Pieter ; Unterberg, Andreas ; Platten, Michael ; Wick, Wolfgang ; Herold-Mende, Christel ; Aldape, Kenneth ; von Deimling, Andreas
Publisher:Berlin/Heidelberg: Springer Berlin Heidelberg
Journal title:Acta neuropathologica, 2015-06, Vol.129 (6), p.867-873
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ArticlesPeer ReviewedFull Text
Extended-representation bisulfite sequencing of gene regulatory elements in multiplexed samples and single cells
Author / Creator:Shareef, Sarah J. ; Bevill, Samantha M. ; Raman, Ayush T. ; Aryee, Martin J. ; van Galen, Peter ; Hovestadt, Volker ; Bernstein, Bradley E.
Publisher:New York: Nature Publishing Group US
Journal title:Nature biotechnology, 2021-09, Vol.39 (9), p.1086-1094
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ArticlesPeer ReviewedFull Text
Explainable artificial intelligence of DNA methylation-based brain tumor diagnostics
Author / Creator:Benfatto, Salvatore ; Sill, Martin ; Jones, David T. W. ; Pfister, Stefan M. ; Sahm, Felix ; von Deimling, Andreas ; Capper, David ; Hovestadt, Volker
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2025-02, Vol.16 (1), p.1787-11, Article 1787
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ArticlesPeer ReviewedFull Text
Prognostic significance of clinical, histopathological, and molecular characteristics of medulloblastomas in the prospective HIT2000 multicenter clinical trial cohort
Author / Creator:Pietsch, Torsten ; Schmidt, Rene ; Remke, Marc ; Korshunov, Andrey ; Hovestadt, Volker ; Jones, David T. W. ; Felsberg, Jörg ; Kaulich, Kerstin ; Goschzik, Tobias ; Kool, Marcel ; Northcott, Paul A. ; von Hoff, Katja ; von Bueren, André O. ; Friedrich, Carsten ; Mynarek, Martin ; Skladny, Heyko ; Fleischhack, Gudrun ; Taylor, Michael D. ; Cremer, Friedrich ; Lichter, Peter ; Faldum, Andreas ; Reifenberger, Guido ; Rutkowski, Stefan ; Pfister, Stefan M.
Publisher:Berlin/Heidelberg: Springer Berlin Heidelberg
Journal title:Acta neuropathologica, 2014-07, Vol.128 (1), p.137-149
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ArticlesPeer ReviewedFull Text
Differential expression and methylation of brain developmental genes define location-specific subsets of pilocytic astrocytoma
Author / Creator:Lambert, Sally R. ; Witt, Hendrik ; Hovestadt, Volker ; Zucknick, Manuela ; Kool, Marcel ; Pearson, Danita M. ; Korshunov, Andrey ; Ryzhova, Marina ; Ichimura, Koichi ; Jabado, Nada ; Fontebasso, Adam M. ; Lichter, Peter ; Pfister, Stefan M. ; Collins, V. Peter ; Jones, David T. W.
Publisher:Berlin/Heidelberg: Springer Berlin Heidelberg
Journal title:Acta neuropathologica, 2013-08, Vol.126 (2), p.291-301
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ArticlesPeer ReviewedFull Text
Arhgap36-dependent activation of Gli transcription factors
Author / Creator:Rack, Paul G. ; Ni, Jun ; Payumo, Alexander Y. ; Nguyen, Vien ; Crapster, J. Aaron ; Hovestadt, Volker ; Kool, Marcel ; Jones, David T. W. ; Mich, John K. ; Firestone, Ari J. ; Pfister, Stefan M. ; Cho, Yoon-Jae ; Chen, James K.
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2014-07, Vol.111 (30), p.11061-11066
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ArticlesPeer ReviewedFull Text
Methylation profiling of paediatric pilocytic astrocytoma reveals variants specifically associated with tumour location and predictive of recurrence
Author / Creator:Sexton‐Oates, Alexandra ; Dodgshun, Andrew ; Hovestadt, Volker ; Jones, David T. W. ; Ashley, David M. ; Sullivan, Michael ; MacGregor, Duncan ; Saffery, Richard
Publisher:United States: John Wiley & Sons, Inc
Journal title:Molecular oncology, 2018-08, Vol.12 (8), p.1219-1232
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ArticlesPeer ReviewedFull Text
Integrative DNA methylation and gene expression analysis in high-grade soft tissue sarcomas
Author / Creator:Renner, Marcus ; Wolf, Thomas ; Meyer, Hannah ; Hartmann, Wolfgang ; Penzel, Roland ; Ulrich, Alexis ; Lehner, Burkhard ; Hovestadt, Volker ; Czwan, Esteban ; Egerer, Gerlinde ; Schmitt, Thomas ; Alldinger, Ingo ; Renker, Eva Kristin ; Ehemann, Volker ; Eils, Roland ; Wardelmann, Eva ; Büttner, Reinhard ; Lichter, Peter ; Brors, Benedikt ; Schirmacher, Peter ; Mechtersheimer, Gunhild
Publisher:England: BioMed Central Ltd
Journal title:Genome Biology (Online Edition), 2013-12, Vol.14 (12), p.r137-r137, Article r137
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ArticlesPeer ReviewedFull Text
DNA methylation-based classification of central nervous system tumours
Author / Creator:Capper, David ; Jones, David T. W. ; Hovestadt, Volker ; Schrimpf, Daniel ; Sturm, Dominik ; Kratz, Annekathrin ; Huang, Kristin ; Pajtler, Kristian W. ; Lindenberg, Kerstin ; Harter, Patrick N. ; Braczynski, Anne K. ; Plate, Karl H. ; Dohmen, Hildegard ; Garvalov, Boyan K. ; Hölsken, Annett ; Hewer, Ekkehard ; Bewerunge-Hudler, Melanie ; Schick, Matthias ; Schittenhelm, Jens ; Wani, Khalida ; Witt, Hendrik ; Milde, Till ; Witt, Olaf ; Giangaspero, Felice ; Geisenberger, Christoph ; Rodriguez, Fausto J. ; Becker, Albert ; Preusser, Matthias ; Haberler, Christine ; Cryan, Jane ; Farrell, Michael ; Deckert, Martina ; Hench, Jürgen ; Frank, Stephan ; Serrano, Jonathan ; Kannan, Kasthuri ; Tsirigos, Aristotelis ; Brück, Wolfgang ; Hofer, Silvia ; Brehmer, Stefanie ; Seiz-Rosenhagen, Marcel ; Hänggi, Daniel ; Rozsnoki, Stephanie ; Hansford, Jordan R. ; Kohlhof, Patricia ; Kristensen, Bjarne W. ; Lechner, Matt ; Lopes, Beatriz ; Mawrin, Christian ; Ketter, Ralf ; Kulozik, Andreas ; Heppner, Frank ; Koch, Arend ; Jouvet, Anne ; Keohane, Catherine ; Mühleisen, Helmut ; Mueller, Wolf ; Driever, Pablo Hernáiz ; Kramm, Christof M. ; Müller, Hermann L. ; Rutkowski, Stefan ; Frühwald, Michael C. ; Gnekow, Astrid ; Fleischhack, Gudrun ; Calaminus, Gabriele ; Perry, Arie ; Jones, Chris ; Jacques, Thomas S. ; Radlwimmer, Bernhard ; Gessi, Marco ; Pietsch, Torsten ; Schramm, Johannes ; Schackert, Gabriele ; Westphal, Manfred ; Reifenberger, Guido ; Wesseling, Pieter ; Weller, Michael ; Bendszus, Martin ; Huang, Annie ; Jabado, Nada ; Northcott, Paul A. ; Paulus, Werner ; Gajjar, Amar ; Taylor, Michael D. ; Ryzhova, Marina ; Platten, Michael ; Unterberg, Andreas ; Wick, Wolfgang ; Acker, Till ; Hartmann, Christian ; Aldape, Kenneth ; Buslei, Rolf ; Lichter, Peter ; Kool, Marcel ; Herold-Mende, Christel ; Ellison, David W. ; Hasselblatt, Martin ; Snuderl, Matija ; Korshunov, Andrey ; Pfister, Stefan M.
Publisher:London: Nature Publishing Group UK
Journal title:Nature (London), 2018-03, Vol.555 (7697), p.469-474
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ArticlesPeer ReviewedFull Text
The whole-genome landscape of medulloblastoma subtypes
Author / Creator:Northcott, Paul A. ; Buchhalter, Ivo ; Morrissy, A. Sorana ; Hovestadt, Volker ; Weischenfeldt, Joachim ; Ehrenberger, Tobias ; Gröbner, Susanne ; Segura-Wang, Maia ; Zichner, Thomas ; Rudneva, Vasilisa A. ; Warnatz, Hans-Jörg ; Sidiropoulos, Nikos ; Phillips, Aaron H. ; Schumacher, Steven ; Kleinheinz, Kortine ; Waszak, Sebastian M. ; Erkek, Serap ; Jones, David T. W. ; Worst, Barbara C. ; Kool, Marcel ; Zapatka, Marc ; Jäger, Natalie ; Chavez, Lukas ; Hutter, Barbara ; Bieg, Matthias ; Paramasivam, Nagarajan ; Heinold, Michael ; Gu, Zuguang ; Ishaque, Naveed ; Jäger-Schmidt, Christina ; Imbusch, Charles D. ; Jugold, Alke ; Hübschmann, Daniel ; Risch, Thomas ; Amstislavskiy, Vyacheslav ; Gonzalez, Francisco German Rodriguez ; Weber, Ursula D. ; Wolf, Stephan ; Robinson, Giles W. ; Zhou, Xin ; Wu, Gang ; Finkelstein, David ; Liu, Yanling ; Cavalli, Florence M. G. ; Luu, Betty ; Ramaswamy, Vijay ; Wu, Xiaochong ; Koster, Jan ; Ryzhova, Marina ; Cho, Yoon-Jae ; Pomeroy, Scott L. ; Herold-Mende, Christel ; Schuhmann, Martin ; Ebinger, Martin ; Liau, Linda M. ; Mora, Jaume ; McLendon, Roger E. ; Jabado, Nada ; Kumabe, Toshihiro ; Chuah, Eric ; Ma, Yussanne ; Moore, Richard A. ; Mungall, Andrew J. ; Mungall, Karen L. ; Thiessen, Nina ; Tse, Kane ; Wong, Tina ; Jones, Steven J. M. ; Witt, Olaf ; Milde, Till ; Von Deimling, Andreas ; Capper, David ; Korshunov, Andrey ; Yaspo, Marie-Laure ; Kriwacki, Richard ; Gajjar, Amar ; Zhang, Jinghui ; Beroukhim, Rameen ; Fraenkel, Ernest ; Korbel, Jan O. ; Brors, Benedikt ; Schlesner, Matthias ; Eils, Roland ; Marra, Marco A. ; Pfister, Stefan M. ; Taylor, Michael D. ; Lichter, Peter
Publisher:London: Nature Publishing Group UK
Journal title:Nature (London), 2017-07, Vol.547 (7663), p.311-317
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ArticlesPeer ReviewedFull Text
Decoupling genetics, lineages, and microenvironment in IDH-mutant gliomas by single-cell RNA-seq
Author / Creator:Venteicher, Andrew S. ; Tirosh, Itay ; Hebert, Christine ; Yizhak, Keren ; Neftel, Cyril ; Filbin, Mariella G. ; Hovestadt, Volker ; Escalante, Leah E. ; Shaw, McKenzie L. ; Rodman, Christopher ; Gillespie, Shawn M. ; Dionne, Danielle ; Luo, Christina C. ; Ravichandran, Hiranmayi ; Mylvaganam, Ravindra ; Mount, Christopher ; Onozato, Maristela L. ; Nahed, Brian V. ; Wakimoto, Hiroaki ; Curry, William T. ; Iafrate, A. John ; Rivera, Miguel N. ; Frosch, Matthew P. ; Golub, Todd R. ; Brastianos, Priscilla K. ; Getz, Gad ; Patel, Anoop P. ; Monje, Michelle ; Cahill, Daniel P. ; Rozenblatt-Rosen, Orit ; Louis, David N. ; Bernstein, Bradley E. ; Regev, Aviv ; Suvà, Mario L.
Publisher:United States: American Association for the Advancement of Science
Journal title:Science (American Association for the Advancement of Science), 2017-03, Vol.355 (6332), p.1391-1391
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ArticlesPeer ReviewedFull Text
Developmental and oncogenic programs in H3K27M gliomas dissected by single-cell RNA-seq
Author / Creator:Filbin, Mariella G. ; Tirosh, Itay ; Hovestadt, Volker ; Shaw, McKenzie L. ; Escalante, Leah E. ; Mathewson, Nathan D. ; Neftel, Cyril ; Frank, Nelli ; Pelton, Kristine ; Hebert, Christine M. ; Haberler, Christine ; Yizhak, Keren ; Gojo, Johannes ; Egervari, Kristof ; Mount, Christopher ; van Galen, Peter ; Bonal, Dennis M. ; Nguyen, Quang-De ; Beck, Alexander ; Sinai, Claire ; Czech, Thomas ; Dorfer, Christian ; Goumnerova, Liliana ; Lavarino, Cinzia ; Carcaboso, Angel M. ; Mora, Jaume ; Mylvaganam, Ravindra ; Luo, Christina C. ; Peyrl, Andreas ; Popović, Mara ; Azizi, Amedeo ; Batchelor, Tracy T. ; Frosch, Matthew P. ; Martinez-Lage, Maria ; Kieran, Mark W. ; Bandopadhayay, Pratiti ; Beroukhim, Rameen ; Fritsch, Gerhard ; Getz, Gad ; Rozenblatt-Rosen, Orit ; Wucherpfennig, Kai W. ; Louis, David N. ; Monje, Michelle ; Slavc, Irene ; Ligon, Keith L. ; Golub, Todd R. ; Regev, Aviv ; Bernstein, Bradley E. ; Suvà, Mario L.
Publisher:United States: The American Association for the Advancement of Science
Journal title:Science (American Association for the Advancement of Science), 2018-04, Vol.360 (6386), p.331-335
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ArticlesPeer ReviewedFull Text
ATRX and IDH1-R132H immunohistochemistry with subsequent copy number analysis and IDH sequencing as a basis for an “integrated” diagnostic approach for adult astrocytoma, oligodendroglioma and gliobla...
Author / Creator:Reuss, David E. ; Sahm, Felix ; Schrimpf, Daniel ; Wiestler, Benedikt ; Capper, David ; Koelsche, Christian ; Schweizer, Leonille ; Korshunov, Andrey ; Jones, David T. W. ; Hovestadt, Volker ; Mittelbronn, Michel ; Schittenhelm, Jens ; Herold-Mende, Christel ; Unterberg, Andreas ; Platten, Michael ; Weller, Michael ; Wick, Wolfgang ; Pfister, Stefan M. ; von Deimling, Andreas
Publisher:Berlin/Heidelberg: Springer Berlin Heidelberg
Journal title:Acta neuropathologica, 2015-01, Vol.129 (1), p.133-146
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INTERNATIONAL PATENT: DEUTSCHES KREBSFORSCHUNGSZENTRUM STIFTUNG DES OFFENTLICHEN RECHTS, UNIVERSITAT HEIDELBERG, SILL, MARTIN, PFISTER, STEFAN, JONES, DAVID, VON DEIMLING, ANDREAS, CAPPER, DAVID, HOVE...

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Machine learning workflows to estimate class probabilities for precision cancer diagnostics on DNA methylation microarray data

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Medulloblastomics revisited: biological and clinical insights from thousands of patients

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Single-cell lineage analysis reveals genetic and epigenetic interplay in glioblastoma drug resistance

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Tagmentation-based whole-genome bisulfite sequencing

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Practical implementation of DNA methylation and copy-number-based CNS tumor diagnostics: the Heidelberg experience

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Second-generation molecular subgrouping of medulloblastoma: an international meta-analysis of Group 3 and Group 4 subtypes

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IDH mutant diffuse and anaplastic astrocytomas have similar age at presentation and little difference in survival: a grading problem for WHO

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Extended-representation bisulfite sequencing of gene regulatory elements in multiplexed samples and single cells

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Explainable artificial intelligence of DNA methylation-based brain tumor diagnostics

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Prognostic significance of clinical, histopathological, and molecular characteristics of medulloblastomas in the prospective HIT2000 multicenter clinical trial cohort

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Differential expression and methylation of brain developmental genes define location-specific subsets of pilocytic astrocytoma

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Arhgap36-dependent activation of Gli transcription factors

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Methylation profiling of paediatric pilocytic astrocytoma reveals variants specifically associated with tumour location and predictive of recurrence

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Integrative DNA methylation and gene expression analysis in high-grade soft tissue sarcomas

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DNA methylation-based classification of central nervous system tumours

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The whole-genome landscape of medulloblastoma subtypes

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Decoupling genetics, lineages, and microenvironment in IDH-mutant gliomas by single-cell RNA-seq

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Developmental and oncogenic programs in H3K27M gliomas dissected by single-cell RNA-seq

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ATRX and IDH1-R132H immunohistochemistry with subsequent copy number analysis and IDH sequencing as a basis for an “integrated” diagnostic approach for adult astrocytoma, oligodendroglioma and gliobla...

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