The cellular basis of GABA(B)-mediated interhemispheric inhibition

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The cellular basis of GABA(B)-mediated interhemispheric inhibition

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The cellular basis of GABA(B)-mediated interhemispheric inhibition

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Full title

The cellular basis of GABA(B)-mediated interhemispheric inhibition

Author / Creator

Palmer, Lucy M , Schulz, Jan M , Murphy, Sean C , Ledergerber, Debora , Murayama, Masanori and Larkum, Matthew E

Publisher

United States

Journal title

Science (American Association for the Advancement of Science), 2012-02, Vol.335 (6071), p.989-993

Language

English

Formats

Articles

Publication information

Publisher

United States

Subjects

Subjects and topics

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Scope and Contents

Contents

Interhemispheric inhibition is thought to mediate cortical rivalry between the two hemispheres through callosal input. The long-lasting form of this inhibition is believed to operate via γ-aminobutyric acid type B (GABA(B)) receptors, but the process is poorly understood at the cellular level. We found that the firing of layer 5 pyramidal neurons i...