Lipid storage disorders block lysosomal trafficking by inhibiting a TRP channel and lysosomal calciu...
Lipid storage disorders block lysosomal trafficking by inhibiting a TRP channel and lysosomal calcium release
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Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Lysosomal lipid accumulation, defects in membrane trafficking and altered Ca
2+
homoeostasis are common features in many lysosomal storage diseases. Mucolipin transient receptor potential channel 1 (TRPML1) is the principle Ca
2+
channel in the lysosome. Here we show that TRPML1-mediated lysosomal Ca
2+
release, measured using a g...
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Full title
Lipid storage disorders block lysosomal trafficking by inhibiting a TRP channel and lysosomal calcium release
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TN_cdi_proquest_miscellaneous_928372681
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_928372681
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/ncomms1735
