Telomere shortening and loss of self-renewal in dyskeratosis congenita induced pluripotent stem cell...
Telomere shortening and loss of self-renewal in dyskeratosis congenita induced pluripotent stem cells
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Author / Creator
Batista, Luis F. Z. , Pech, Matthew F. , Zhong, Franklin L. , Nguyen, Ha Nam , Xie, Kathleen T. , Zaug, Arthur J. , Crary, Sharon M. , Choi, Jinkuk , Sebastiano, Vittorio , Cherry, Athena , Giri, Neelam , Wernig, Marius , Alter, Blanche P. , Cech, Thomas R. , Savage, Sharon A. , Reijo Pera, Renee A. and Artandi, Steven E.
Publisher
London: Nature Publishing Group UK
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English
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Publisher
London: Nature Publishing Group UK
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Contents
A novel iPS cell disease model
Dyskeratosis congenita, a disease characterized by defective maintenance of blood, pulmonary and epidermal tissues, is caused by defects in genes required for telomere homeostasis. Short telomeres are thought to cause signs of the disease in mouse models by inducing senescence and cell death responses that impair t...
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Telomere shortening and loss of self-renewal in dyskeratosis congenita induced pluripotent stem cells
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TN_cdi_proquest_miscellaneous_968160191
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_968160191
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ISSN
0028-0836
E-ISSN
1476-4687
DOI
10.1038/nature10084
