"The protease derived from Nocardiopsis sp. (SEQ ID NO: 1), as well as its preparation and various industrial applications thereof are described in WO 88/03947 and WO 01/58276. Related proteases are described in WO 2004/111220, WO 2004/111222, WO 2004/111223, WO 2004/111221, WO 2005/035747, WO 2004/111219, WO 2005/123911, and JP 2003284571-A (GENESEQP:ADF43564). Supplementing the background information on this patent, NewsRx reporters also obtained the inventors' summary information for this patent: "The present invention relates to a protease having at least 90% identity to amino acids 1-188 of SEQ ID NO: 1, and which, as compared to amino acids 1-188 of SEQ ID NO: 1, comprises at least one substitution selected from the following substitutions: A1T; I3V; G12; R14I; T22A; N23D; G34A; R38; T41A; T44K; N47; G48D; E53K; Q54L,D; T68A,R,S; S69T; L73P; V88A; S99P; P124L; E125; M131V; T151I; R165; and T166A. For the URL and additional information on this patent, see: Svendsen, Allan; Beier, Lars; [Larsen], [Signe Eskildsen]; Lenhard, Thomas; Kjaer, [Tanja Maria Rosenkilde]; Gregory, Peter Colin. Protease Variants for Pharmaceutical Use. U.S. Patent Number 8455235, filed December 2, 2008, and published online on June 4, 2013. Patent URL: http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO2&Sect2=HITOFF&p=80&u=%2Fnetahtml%2FPTO%2Fsearch-bool.html&r=3992&f=G&l=50&co1=AND&d=PTXT&s1=20130604.PD.&OS=ISD/20130604&RS=ISD/20130604...

Novozymes A/S; Patent Issued for Protease Variants for Pharmaceutical Use