Guanosine Triphosphatase Stimulation of Oncogenic Ras Mutants
Guanosine Triphosphatase Stimulation of Oncogenic Ras Mutants
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Publisher
United States: National Academy of Sciences of the United States of America
Journal title
Language
English
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Publisher
United States: National Academy of Sciences of the United States of America
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Scope and Contents
Contents
Interest in the guanosine triphosphatase (GTPase) reaction of Ras as a molecular drug target stems from the observation that, in a large number of human tumors, Ras is characteristically mutated at codons 12 or 61, more rarely 13. Impaired GTPase activity, even in the presence of GTPase activating proteins, has been found to be the biochemical reas...
Alternative Titles
Full title
Guanosine Triphosphatase Stimulation of Oncogenic Ras Mutants
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Record Identifier
TN_cdi_pubmed_primary_10359839
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmed_primary_10359839
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.96.12.7065
