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Guanosine Triphosphatase Stimulation of Oncogenic Ras Mutants

Guanosine Triphosphatase Stimulation of Oncogenic Ras Mutants

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmed_primary_10359839

Guanosine Triphosphatase Stimulation of Oncogenic Ras Mutants

About this item

Full title

Guanosine Triphosphatase Stimulation of Oncogenic Ras Mutants

Publisher

United States: National Academy of Sciences of the United States of America

Journal title

Proceedings of the National Academy of Sciences - PNAS, 1999-06, Vol.96 (12), p.7065-7070

Language

English

Formats

Publication information

Publisher

United States: National Academy of Sciences of the United States of America

More information

Scope and Contents

Contents

Interest in the guanosine triphosphatase (GTPase) reaction of Ras as a molecular drug target stems from the observation that, in a large number of human tumors, Ras is characteristically mutated at codons 12 or 61, more rarely 13. Impaired GTPase activity, even in the presence of GTPase activating proteins, has been found to be the biochemical reas...

Alternative Titles

Full title

Guanosine Triphosphatase Stimulation of Oncogenic Ras Mutants

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_pubmed_primary_10359839

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmed_primary_10359839

Other Identifiers

ISSN

0027-8424

E-ISSN

1091-6490

DOI

10.1073/pnas.96.12.7065

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