Mmh/Ogg1 Gene Inactivation Results in Accumulation of 8-Hydroxyguanine in Mice
Mmh/Ogg1 Gene Inactivation Results in Accumulation of 8-Hydroxyguanine in Mice
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United States: National Academy of Sciences of the United States of America
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Language
English
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United States: National Academy of Sciences of the United States of America
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Contents
The major mutagenic base lesion in DNA caused by exposure to reactive oxygen species is 8-hydroxyguanine or 7,8-dihydro-8-oxoguanine (8-OH-G). Products of the human MMH/OGG1 gene are known to catalyze in vitro the reactions repairing this DNA lesion. To analyze the function of Mmh in vivo, we generated a mouse line carrying a mutant Mmh allele by t...
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Full title
Mmh/Ogg1 Gene Inactivation Results in Accumulation of 8-Hydroxyguanine in Mice
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TN_cdi_pubmed_primary_10725358
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmed_primary_10725358
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ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.050404497
