Preselection of Retrovirally Transduced Bone Marrow Avoids Subsequent Stem Cell Gene Silencing and A...
Preselection of Retrovirally Transduced Bone Marrow Avoids Subsequent Stem Cell Gene Silencing and Age-Dependent Extinction of Expression of Human β -Globin in Engrafted Mice
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Publisher
United States: National Academy of Sciences of the United States of America
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Language
English
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United States: National Academy of Sciences of the United States of America
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Contents
Transcriptional silencing of genes transferred into hematopoietic stem cells poses one of the most significant challenges to the success of gene therapy. If the transferred gene is not completely silenced, a progressive decline in gene expression as the mice age often is encountered. These phenomena were observed to various degrees in mouse transpl...
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Full title
Preselection of Retrovirally Transduced Bone Marrow Avoids Subsequent Stem Cell Gene Silencing and Age-Dependent Extinction of Expression of Human β -Globin in Engrafted Mice
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TN_cdi_pubmed_primary_10792053
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmed_primary_10792053
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ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.100082597
