Assembly of tau protein into Alzheimer paired helical filaments depends on a local sequence motif ((...
Assembly of tau protein into Alzheimer paired helical filaments depends on a local sequence motif ((306)VQIVYK(311)) forming beta structure
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United States
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English
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United States
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We have searched for a minimal interaction motif in tau protein that supports the aggregation into Alzheimer-like paired helical filaments. Digestion of the repeat domain with different proteases yields a GluC-induced fragment comprising 43 residues (termed PHF43), which represents the third repeat of tau plus some flanking residues. This fragment...
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Assembly of tau protein into Alzheimer paired helical filaments depends on a local sequence motif ((306)VQIVYK(311)) forming beta structure
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TN_cdi_pubmed_primary_10805776
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmed_primary_10805776
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ISSN
0027-8424
DOI
10.1073/pnas.97.10.5129
