IL-27 Regulates IL-12 Responsiveness of naïve CD4+T Cells through Stat1-Dependent and -Independent M...
IL-27 Regulates IL-12 Responsiveness of naïve CD4+T Cells through Stat1-Dependent and -Independent Mechanisms
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United States: National Academy of Sciences
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English
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United States: National Academy of Sciences
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IL-27, a novel heterodimeric cytokine produced by antigen-presenting cells, signals through the T cell cytokine receptor (TCCR)/WSX-1expressed on$na{\ddot \imath} ve\>CD4^+$T cells and natural killer cells. TCCR/WSX-1deficiency results in delayed T helper type 1 (TH1) development through an unresolved mechanism. We report here that IL-27 stimulatio...
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Full title
IL-27 Regulates IL-12 Responsiveness of naïve CD4+T Cells through Stat1-Dependent and -Independent Mechanisms
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TN_cdi_pubmed_primary_14657353
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmed_primary_14657353
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ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.2536517100
