A Tlr7 Translocation Accelerates Systemic Autoimmunity in Murine Lupus
A Tlr7 Translocation Accelerates Systemic Autoimmunity in Murine Lupus
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Publisher
United States: National Academy of Sciences
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Language
English
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Publisher
United States: National Academy of Sciences
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Contents
The y-linked autoimmune accelerating (yaa) locus is a potent autoimmune disease allele. Transcription profiling of yaa-bearing B cells revealed the overexpression of a cluster of X-linked genes that included T/r7. FISH analysis demonstrated the translocation of this segment onto the yaa chromosome. The resulting overexpression of T/r7 increased in...
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Full title
A Tlr7 Translocation Accelerates Systemic Autoimmunity in Murine Lupus
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TN_cdi_pubmed_primary_16777955
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmed_primary_16777955
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ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.0603912103
