Hydrogen peroxide scavenging rescues frataxin deficiency in a Drosophila model of Friedreich's ataxi...
Hydrogen peroxide scavenging rescues frataxin deficiency in a Drosophila model of Friedreich's ataxia
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United States: National Academy of Sciences
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English
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United States: National Academy of Sciences
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Friedreich's ataxia (FRDA) is a neurodegenerative disorder arising from a deficit of the mitochondrial iron chaperone, frataxin. Evidence primarily from yeast and mammalian cells is consistent with the hypothesis that a toxic hydroxyl radical generated from hydrogen peroxide (H₂O₂) via iron-catalyzed Fenton chemistry at least partially underlies th...
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Hydrogen peroxide scavenging rescues frataxin deficiency in a Drosophila model of Friedreich's ataxia
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TN_cdi_pubmed_primary_18184803
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmed_primary_18184803
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ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.0709691105
