Core epithelial-to-mesenchymal transition interactome gene-expression signature is associated with c...
Core epithelial-to-mesenchymal transition interactome gene-expression signature is associated with claudin-low and metaplastic breast cancer subtypes
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Author / Creator
Taube, Joseph H. , Herschkowitz, Jason I. , Komurov, Kakajan , Zhou, Alicia Y. , Gupta, Supriya , Yang, Jing , Hartwell, Kimberly , Onder, Tamer T. , Gupta, Piyush B. , Evans, Kurt W. , Hollier, Brett G. , Ram, Prahlad T. , Lander, Eric S. , Rosen, Jeffrey M. , Weinberg, Robert A. and Mani, Sendurai A.
Publisher
United States: National Academy of Sciences
Journal title
Language
English
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Publisher
United States: National Academy of Sciences
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Scope and Contents
Contents
The epithelial-to-mesenchymal transition (EMT) produces cancer cells that are invasive, migratory, and exhibit stem cell characteristics, hallmarks of cells that have the potential to generate metastases. Inducers of the EMT include several transcription factors (TFs), such as Goosecoid, Snail, and Twist, as well as the secreted TGF-β1. Each of the...
Alternative Titles
Full title
Core epithelial-to-mesenchymal transition interactome gene-expression signature is associated with claudin-low and metaplastic breast cancer subtypes
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Record Identifier
TN_cdi_pubmed_primary_20713713
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmed_primary_20713713
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1004900107
