Distinct DNA methylomes of newborns and centenarians
Distinct DNA methylomes of newborns and centenarians
About this item
Full title
Author / Creator
Heyn, Holger , Li, Ning , Ferreira, Humberto J. , Moran, Sebastian , Pisano, David G. , Gomez, Antonio , Diez, Javier , Sanchez-Mut, Jose V. , Setien, Fernando , Carmona, F. Javier , Puca, Annibale A. , Sayols, Sergi , Pujana, Miguel A. , Serra-Musach, Jordi , Iglesias-Platas, Isabel , Formiga, Francesc , Fernandez, Agustin F. , Fraga, Mario F. , Heath, Simon C. , Valencia, Alfonso , Gut, Ivo G. , Wang, Jun and Esteller, Manel
Publisher
United States: National Academy of Sciences
Journal title
Language
English
Formats
Publication information
Publisher
United States: National Academy of Sciences
Subjects
More information
Scope and Contents
Contents
Human aging cannot be fully understood in terms of the constrained genetic setting. Epigenetic drift is an alternative means of explaining age-associated alterations. To address this issue, we performed whole-genome bisulfite sequencing (WGBS) of newborn and centenarian genomes. The centenarian DNA had a lower DNA methylation content and a reduced...
Alternative Titles
Full title
Distinct DNA methylomes of newborns and centenarians
Authors, Artists and Contributors
Author / Creator
Li, Ning
Ferreira, Humberto J.
Moran, Sebastian
Pisano, David G.
Gomez, Antonio
Diez, Javier
Sanchez-Mut, Jose V.
Setien, Fernando
Carmona, F. Javier
Puca, Annibale A.
Sayols, Sergi
Pujana, Miguel A.
Serra-Musach, Jordi
Iglesias-Platas, Isabel
Formiga, Francesc
Fernandez, Agustin F.
Fraga, Mario F.
Heath, Simon C.
Valencia, Alfonso
Gut, Ivo G.
Wang, Jun
Esteller, Manel
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmed_primary_22689993
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmed_primary_22689993
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1120658109
