Structure and inhibition of the drug-resistant S31N mutant of the M2 ion channel of influenza A viru...
Structure and inhibition of the drug-resistant S31N mutant of the M2 ion channel of influenza A virus
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United States: National Academy of Sciences
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Language
English
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Publisher
United States: National Academy of Sciences
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Contents
The influenza A virus M2 proton channel (A/M2) is the target of the antiviral drugs amantadine and rimantadine, whose use has been discontinued due to widespread drug resistance. Among the handful of drug-resistant mutants, S31N is found in more than 95% of the currently circulating viruses and shows greatly decreased inhibition by amantadine. The...
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Full title
Structure and inhibition of the drug-resistant S31N mutant of the M2 ion channel of influenza A virus
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TN_cdi_pubmed_primary_23302696
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmed_primary_23302696
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ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1216526110
