Developmental timing of mutations revealed by whole-genome sequencing of twins with acute lymphoblas...
Developmental timing of mutations revealed by whole-genome sequencing of twins with acute lymphoblastic leukemia
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Publisher
United States: National Academy of Sciences
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Language
English
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Publisher
United States: National Academy of Sciences
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Contents
Acute lymphoblastic leukemia (ALL) is the major pediatric cancer. At diagnosis, the developmental timing of mutations contributing critically to clonal diversification and selection can be buried in the leukemia's covert natural history. Concordance of ALL in monozygotic, monochorionic twins is a consequence of intraplacental spread of an initiated...
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Full title
Developmental timing of mutations revealed by whole-genome sequencing of twins with acute lymphoblastic leukemia
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TN_cdi_pubmed_primary_23569245
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmed_primary_23569245
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ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1221099110
