Aβ-induced Golgi fragmentation in Alzheimer’s disease enhances Aβ production
Aβ-induced Golgi fragmentation in Alzheimer’s disease enhances Aβ production
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United States: National Academy of Sciences
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Language
English
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Publisher
United States: National Academy of Sciences
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Golgi fragmentation occurs in neurons of patients with Alzheimer’s disease (AD), but the underlying molecular mechanism causing the defects and the subsequent effects on disease development remain unknown. In this study, we examined the Golgi structure in APPswe/PS1E9 transgenic mouse and tissue culture models. Our results show that accumulation of...
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Full title
Aβ-induced Golgi fragmentation in Alzheimer’s disease enhances Aβ production
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TN_cdi_pubmed_primary_24639524
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmed_primary_24639524
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ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1320192111
