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Microbial-induced meprin β cleavage in MUC2 mucin and a functional CFTR channel are required to rele...

Microbial-induced meprin β cleavage in MUC2 mucin and a functional CFTR channel are required to rele...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmed_primary_25114233

Microbial-induced meprin β cleavage in MUC2 mucin and a functional CFTR channel are required to release anchored small intestinal mucus

About this item

Full title

Microbial-induced meprin β cleavage in MUC2 mucin and a functional CFTR channel are required to release anchored small intestinal mucus

Publisher

United States: National Academy of Sciences

Journal title

Proceedings of the National Academy of Sciences - PNAS, 2014-08, Vol.111 (34), p.12396-12401

Language

English

Formats

Publication information

Publisher

United States: National Academy of Sciences

More information

Scope and Contents

Contents

The mucus that covers and protects the epithelium of the intestine is built around its major structural component, the gel-forming MUC2 mucin. The gel-forming mucins have traditionally been assumed to be secreted as nonattached. The colon has a two-layered mucus system where the inner mucus is attached to the epithelium, whereas the small intestine...

Alternative Titles

Full title

Microbial-induced meprin β cleavage in MUC2 mucin and a functional CFTR channel are required to release anchored small intestinal mucus

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_pubmed_primary_25114233

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmed_primary_25114233

Other Identifiers

ISSN

0027-8424,1091-6490

E-ISSN

1091-6490

DOI

10.1073/pnas.1407597111

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