Cleavage of roquin and regnase-1 by the paracaspase MALT1 releases their cooperatively repressed tar...
Cleavage of roquin and regnase-1 by the paracaspase MALT1 releases their cooperatively repressed targets to promote T(H)17 differentiation
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Full title
Author / Creator
Jeltsch, Katharina M , Hu, Desheng , Brenner, Sven , Zöller, Jessica , Heinz, Gitta A , Nagel, Daniel , Vogel, Katharina U , Rehage, Nina , Warth, Sebastian C , Edelmann, Stephanie L , Gloury, Renee , Martin, Nina , Lohs, Claudia , Lech, Maciej , Stehklein, Jenny E , Geerlof, Arie , Kremmer, Elisabeth , Weber, Achim , Anders, Hans-Joachim , Schmitz, Ingo , Schmidt-Supprian, Marc , Fu, Mingui , Holtmann, Helmut , Krappmann, Daniel , Ruland, Jürgen , Kallies, Axel , Heikenwalder, Mathias and Heissmeyer, Vigo
Publisher
United States
Journal title
Language
English
Formats
Publication information
Publisher
United States
Subjects
More information
Scope and Contents
Contents
Humoral autoimmunity paralleled by the accumulation of follicular helper T cells (T(FH) cells) is linked to mutation of the gene encoding the RNA-binding protein roquin-1. Here we found that T cells lacking roquin caused pathology in the lung and accumulated as cells of the T(H)17 subset of helper T cells in the lungs. Roquin inhibited T(H)17 cell...
Alternative Titles
Full title
Cleavage of roquin and regnase-1 by the paracaspase MALT1 releases their cooperatively repressed targets to promote T(H)17 differentiation
Authors, Artists and Contributors
Author / Creator
Hu, Desheng
Brenner, Sven
Zöller, Jessica
Heinz, Gitta A
Nagel, Daniel
Vogel, Katharina U
Rehage, Nina
Warth, Sebastian C
Edelmann, Stephanie L
Gloury, Renee
Martin, Nina
Lohs, Claudia
Lech, Maciej
Stehklein, Jenny E
Geerlof, Arie
Kremmer, Elisabeth
Weber, Achim
Anders, Hans-Joachim
Schmitz, Ingo
Schmidt-Supprian, Marc
Fu, Mingui
Holtmann, Helmut
Krappmann, Daniel
Ruland, Jürgen
Kallies, Axel
Heikenwalder, Mathias
Heissmeyer, Vigo
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmed_primary_25282160
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmed_primary_25282160
Other Identifiers
E-ISSN
1529-2916
DOI
10.1038/ni.3008
