LIMP-2 expression is critical for β-glucocerebrosidase activity and α-synuclein clearance
LIMP-2 expression is critical for β-glucocerebrosidase activity and α-synuclein clearance
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United States: National Academy of Sciences
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English
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United States: National Academy of Sciences
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Significance Our report highlights, for the first time to our knowledge, a distinct relationship between lysosomal integral membrane protein type-2 (LIMP-2) expression, β-glucocerebrosidase (GC) activity, and clearance of α-synuclein. In LIMP-2–deficient mice, increased levels of endogenous α-synuclein led to severe neurological deficits and premat...
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LIMP-2 expression is critical for β-glucocerebrosidase activity and α-synuclein clearance
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TN_cdi_pubmed_primary_25316793
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmed_primary_25316793
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ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1405700111
