Cooperative folding of a polytopic α-helical membrane protein involves a compact N-terminal nucleus...
Cooperative folding of a polytopic α-helical membrane protein involves a compact N-terminal nucleus and nonnative loops
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United States: National Academy of Sciences
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English
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United States: National Academy of Sciences
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Despite the ubiquity of helical membrane proteins in nature and their pharmacological importance, the mechanisms guiding their folding remain unclear. We performed kinetic folding and unfolding experiments on 69mutants (engineered every 2–3 residues throughout the 178-residue transmembrane domain) of GlpG, a membrane-embedded rhomboid protease from...
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Cooperative folding of a polytopic α-helical membrane protein involves a compact N-terminal nucleus and nonnative loops
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TN_cdi_pubmed_primary_26056273
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmed_primary_26056273
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ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1424751112
